Half-lives of the SSRIs under steady state conditions depends on the individual drug. Your partner also might be upset with the change in sexual intimacy. Ultimately, when prescribing SSRIs to any patient, a risk—benefit analysis must factor in the potential treatment effects, adverse effects, and dangers of the illness to be treated. Importantly, the partners of subjects in these trials also reported significant improvements in satisfaction with sexual intercourse at every time point, suggesting possible associated reductions in interpersonal difficulty not measured in these studies. Serotonin syndrome is a life-threatening consequence of increased serotonergic activity. Additionally, SSRIs are often combined with other pharmacological agents to increase efficacy. Gastrointestinal Disorders Gastrointestinal GI disorders are frequently comorbid in patients with depression and anxiety disorders [ 53 , 54 , 55 ].rows · Background Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by . Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE. Early trials with dapoxetine have documented successful outcomes without serious .  · Dapoxetine (Priligy™ Johnson and Johnson, NJ, USA) is a novel SSRI, which acts by potent inhibition of 5-HT transport. As a short acting SSRI, Author: Abdulmuttalip Simsek, Sinan Levent Kirecci, Onur Kucuktopcu, Faruk Ozgor, Mehmet Fatih Akbulut, Omer.