Take care if you are a driver. PDE5 inhibitors. Before taking dapoxetine Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. Renal impairment. Patients must not take more than one tablet once every 24 hours due to increased risk of side effects see Boxed Warnings and lack of additional benefit. Of these subjects, received Priligy 30 mg as needed and received placebo. The integrated analysis by Porst et al of two studies showed no differences in control over ejaculation between those with lifelong or acquired PE and no erectile dysfunction , suggesting that the etiology of the two forms may be similar, given that dapoxetine treatment was equally effective.Combining alcohol with dapoxetine may increase these alcohol-related effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Priligy (see sections and ). PRILIGY contains the active ingredient dapoxetine and is a type of drug called a selective serotonin reuptake inhibitor (SSRI) and it is also known as a urological medicine. PRILIGY increases your time to ejaculation and can improve your control over ejaculation and reduce your distress over how fast you ejaculate. Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay.