It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day. Each film-coated tablet contains either 30 mg or 60 mg dapoxetine hydrochloride, and may be administered with or without food. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Continue to take sildenafil even if you feel well.Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity. Maintenance: 25 to mg orally once a day, as needed, 1 hour prior to sexual activity. . Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE. This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult . Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles .