If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. Once you’ve identified your pelvic floor muscles, you can exercise them in any position. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. After 24 weeks of dapoxetine therapy, the trial by Buvat et al found Tighten your pelvic floor muscles, hold for three seconds and then relax for three seconds. The efficacy and safety of topical anaesthetics and SSRIs in delaying ejaculation have been confirmed in many well-designed controlled trials. However, some countries have not approved its use.Premature ejaculation (PE) is a prevalent male sexual dysfunction. Current standard treatment regimens include behavioural therapies, topical anaesthetics, dapoxetine and other selective. The SSRI dapoxetine is often used as the first treatment for premature ejaculation in some countries. It’s not currently available in the United States. Of the drugs approved for use in the United States, paroxetine seems to be the most effective. For the drug treatment for PE, gold standard is selective serotonin reuptake inhibitors (SSRIs) including dapoxetine or paroxetine. The drug treatment for PE is still developing and some new promising therapeutic options have been proposed.