This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase 1, 2 and 3 efficacy and safety studies and drug-interaction studies. Literature search methodology All dapoxetine drug-treatment reports and studies were included in the review. If you have increased pressure in your eye, a condition called glaucoma. Both integrated analyses found significant reductions in distress related to ejaculation at study endpoint following dapoxetine treatment. Definition, prevalence and aetiology of premature ejaculation Definition There are multiple definitions of PE [ American Psychiatric Association, ; Hatzimouratidis et al. · The starting dose for all patients is 30 mg. Take as needed approximately 1 to 3 hours prior to sexual activity. Treatment with dapoxetine should not be initiated with the 60 mg dose. Dapoxetine is not intended for continuous daily use. The most common treatment-related adverse effects included nausea (% for 30 mg, % for 60 mg), dizziness (% for 30 mg, % for 60 mg), and headache (% for 30 mg, % for 60 mg), and evaluation of validated rated scales demonstrated no SSRI class-related effects with dapoxetine use. The maximum dose of dapoxetine should be 30 mg if dapoxetine is combined with any of these drugs (see sections , and below). These two measures apply to all patients unless the patient has been verified to be a CYP2D6 extensive metabolizer by geno- .