Results Of all patients, 9. The first contemporary multivariate evidence-based definition of lifelong PE was developed in by a panel of international experts, convened by the International Society for Sexual Medicine ISSM , who agreed that the diagnostic criteria necessary to define PE are time from penetration to ejaculation, inability to delay ejaculation and negative personal consequences from PE. Adequately powered randomized, controlled trials were considered the strongest form of evidence but all other articles were also considered. Both integrated analyses found significant reductions in distress related to ejaculation at study endpoint following dapoxetine treatment. What treatment approach do you recommend?Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE. This paper reviews the current evidence for use of dapoxetine in the treatment .  · Although dapoxetine is the only oral pharmacologic agent approved for the treatment of premature ejaculation (PE) and is very effective, the discontinuation rate is .  · After three months, the men taking a milligram dose of dapoxetine took an average minutes to ejaculate after penetration, those on a milligram dose took .