You take one 2. They are PDE5 inhibitors that allow for increased blood flow to the penis, leading to more frequent and harder erections. According to the FDA, generic medications contain the same active ingredients as brand names, meaning there’s no difference in effectiveness or safety. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. Interestingly, Cialis has been more linked to improved self-esteem and other psychological factors than the other PDE5 medications. Click here for an email preview. Other conditions that may disqualify you from an ED prescription include a history of stroke, kidney or liver disease, cancer, diabetes, or a bleeding disorder.Cialis is a popular ED medication. Find out everything you need to know about this doctor-prescribed medication including usage, effectiveness, and safety . Cialis has an average rating of out of 10 from a total of ratings on 83% of reviewers reported a positive effect, while 9% reported a negative effect. Sildenafil has an average rating of out of 10 from a total of ratings on 78% of reviewers reported a positive effect, while 13% reported a negative effect. The dose of Cialis you need will depend on whether you’re taking it daily or as needed. Daily doses are often between and 5 milligrams (mg). The as-needed dose is usually 10 mg but can range from 5–20 mg. The typicaldose of Viagra is 50 mg. However, the dosage can range from 25– mg.